I led and directed a computational medicine research program as a Principal Investigator at MIT. We reported several novel and unorthodox technology solutions encompassing engineering, biomarker imaging, machine learning and clinical data to invent low-cost diagnostics and therapeutics, and subsequent real-world deployment platforms to provide inclusive and affordable medical care to everyone. I served as the sole principal investigator on the Memorandum of Understanding (MOU) ‘Health 0.0’ with the United States FDA signed to engender AI and machine learning research collaborations for computational medicine and clinical development. Research findings from my lab were published in Cell Reports Methods, Nature Digital Medicine, Cell press, Journal of American Medical Association, and workshop proceedings of The National Academies of Science Engineering and Medicine.