Rapid fabrication and integration of medical devices and technologies

My lab has significant expertise and motivation to bring problems from the clinic and society into the laboratory to develop novel bioengineering solutions and perform real world prospective clinical evaluations. I have supported patients and physicians by providing innovative medical technologies using mobile phones, microfluidics, and digital devices for generating at home and point-of-care real world data and evidence.

  • For example, in a study published in the British Medical Journal I led research that evaluated the significance and efficacy of real-world data generated from the United States Food and Drug Administration approved advanced technology-enabled, non-invasive diagnostic screening (TES) smartphones and other point-of-care medical imaging devices vs. conventional vital signs examinations [1]. This study led to significant insights regarding strategies for developing TES technologies that are ready for deployment and designed for effective and scalable primary care and real-world evidence generation.
  • In collaboration with MIT Mechanical Engineering, I am a Co-Principal Investigator on a grant developing an affinity ligand-based whole-cell capture, concentration, and culture for sensitive pathogen detection food safety tests [Press]. This microfluidic microbiological assay is suitable for implementation in an integrated benchtop device for use by technicians directly at production sites in a format that preserves cells for further downstream testing [R1].
  • In collaboration with MIT Chemical Engineering and other researchers I have developed and published protocols for a point-of-care lateral flow diagnostic strip and bio-digital wearable devices to detect biomarkers in human saliva samples. Biomarkers such as matrix metalloproteinases-8 and -9, pH and nitric oxide linked to oral diseases, stress and human physiology have been successfully integrated with these platforms [2, 3].
  • I published a study evaluating a low-cost mask to screen for sleep apnea through physiological monitoring: respiratory activity (airflow and nasal air pressure) and sleep behavior (motion and noise) [4].
  • My research lab has also published construction and validation of low-cost, point-of-care, near-infrared imaging devices to diagnose dental caries, cracks, and demineralization without the use of ionizing X-rays [5, 6, 7].
  • I have open-sourced the construction and the algorithm of porphyrin imaging devices and a clip that can be used on a mobile phone camera [8].

Peer-Reviewed Publications

  1. Technology-enabled examinations of cardiac rhythm, optic nerve, oral health, tympanic membrane, gait and coordination evaluated jointly with routine health screenings: an observational study at the 2015 Kumbh Mela in India. 2018. [Abstract] [Full Paper]

    Pratik Shah*, Yauney G, Gupta O, Patalano V, Mohit M, Merchant R, Subramanian SV

    (*Senior author supervising research, Contributed equally)

    The British Medical Journal Open. PMID: 29678964

  2. Detection of biomarkers of periodontal disease in human saliva using stabilized, vertical flow immunoassays. 2017. [Abstract] [Full Paper]

    Emma Yee, Lathwal S, Shah P, Sikes H

    ACS Sensors. PMID: 29090909

  3. Wearable lab on body: combining sensing of biochemical and digital markers in a wearable device. 2019. [Abstract] [Full Paper]

    Pat Pataranutaporn, Jain A, Johnson C, Shah P, Maes P

    41st IEEE EMBC Conference. PMID: 31946594

  4. Design and preliminary evaluation of a wearable device for mass screening of sleep apnea. 2016. [Abstract] [Full Paper]

    Rohan Puri, Athanasios A, Gill N, Sathya S, Rathod G, Wahi A, Satat G, Majmudar M, Shah P*

    (*Senior author supervising research)

    Conf Proc IEEE Eng Med Biol Soc. PMID: 28268691

  5. Digital reconstruction of teeth using near-infrared light. 2019. [Abstract] [Full Paper]

    Keith Angelino, Yauney G, Rana A, Muftu A, Edlund D, Shah P*

    (*Senior author supervising research)

    41st IEEE International Engineering in Medicine and Biology Conference. DOI: 10.1109/EMBC.2019.8857734

  6. Near-infrared transillumination guides administration of dental 2D radiography and CBCT imaging. 2017. [Abstract] [Full Paper]

    Keith Angelino, Edlund D, Bhatia G, Wu S, Shah P*

    (*Senior author supervising research, Selected for oral presentation)

    17th annual IEEE International Conference on BioInformatics and BioEngineering. DOI: 10.1109/BIBE.2017.00-33

  7. Near-infrared imaging for detecting caries and structural deformities in teeth. 2017. [Abstract] [Full Paper]

    Keith Angelino, Edlund D and Shah P*

    (*Senior author supervising research)

    Journal of Translational Engineering in Health and Medicine. PMID: 28507826

  8. Clinical validation and assessment of a modular fluorescent imaging system and algorithm for rapid detection and quantification of dental plaque. 2017. [Abstract] [Full Paper]

    Pratik Shah*, Angelino K, Edlund D, Mohit M, Yauney G

    (*Senior author supervising research, Contributed equally)

    BMC Oral. PMID: 29284461


  • R1 - On-site Analysis of Foodborne Pathogens Using Density-Shift Immunomagnetic Separation and Culture [Link]

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