I am a tenure line faculty member and professor at the University of California and lead a computational medicine group for hypothesis-driven deep learning, engineering, and biomedical research to discover novel biological and clinical knowledge for inventing translational medical technologies to diagnose and treat cancer, infectious, and neurological diseases. I also have significant expertise and motivation for real-world clinical evaluations of research findings. Research in my lab builds a unified scaffolding of novel deep learning, biological, and statistical reasoning methods to resolve distinct hypothesis driven research problems including, for example, how to diagnose and treat cancer disease at the cellular level, how to generate novel medical images for unbiased patient-centered medicine, and what is the impact of clinical decision-making on infectious disease and antimicrobial therapy – under a single theoretical and methodological framework. My research group aims to establish a new theory and practice for computational medicine research by moving the field from a static snapshot to a fully dynamic and living-systems wide perspective of molecular and clinical processes. My team and I are motivated to invent and deploy pragmatic and equitable medical technology for improving health and managing diseases.