Low-cost, open source and point-of-care deployment of medical technologies

Key challenges that prevent transitioning medical technologies from bench-to-bedside include costs of product development, requirement of trained operators, point-of-care costs associated with administering the tests and lack of clear value propositions to patients and physicians. In a study, currently in press in the British Medical Journal, we evaluated significance and efficacy of advanced technology-enabled non-invasive diagnostic screening (TES) using smartphones and other point-of-care medical imaging devices vs. conventional vital sign examinations [1]. This study led to significant insights about strategies to develop technologies at MIT that are ready for deployment for effective and scalable primary care in the real world. For e.g. a) We have open-sourced the construction and the algorithm of porphyrin imaging devices and also created a cell-phone clip on that can use a mobile phone camera [2]. b) For biomarkers, such as matrix metalloproteinases-8 and -9 linked to periodontal diseases, that cannot be imaged, in collaboration with MIT Chemical Engineering, we have developed and published protocols for POC lateral flow diagnostic strip to detect it from human saliva samples [3]. c) Construction and validation of low-cost, point-of-care near-infrared imaging devices to diagnose dental caries, cracks and demineralization without use of ionizing X-rays has been published [4, 5]. d) A low-cost mask to screen for sleep apnea by physiological monitoring: respiratory activity (airflow and nasal air pressure) and sleep behavior (motion and noise) has been published [6].


  1. 2018. Evaluation of technology-enabled examinations of cardiac rhythm, optic nerve, oral health, tympanic membrane, gait and coordination jointly with routine health screenings

    Pratik Shah*, Yauney G, Gupta O, Patalano V, Mohit M, Merchant R, Subramanian SV

    (*Senior author supervising research, Contributed equally)

    The British Medical Journal Open, in press March 2018,

  2. 2017. Clinical validation and assessment of a modular fluorescent imaging system and algorithm for rapid detection and quantification of dental plaque [Abstract] [Full Paper]

    Pratik Shah*, Angelino K, Edlund D, Mohit M, Yauney G

    (*Senior author supervising research, Contributed equally)

    BMC Oral, 2017, PMID: 29284461

  3. 2017. Detection of biomarkers of periodontal disease in human saliva using stabilized, vertical flow immunoassays [Abstract] [Full Paper]

    Emma Yee, Lathwal S, Shah P, Sikes H

    ACS Sensors, 2017, PMID: 29090909

  4. 2017. Near-infrared transillumination guides administration of dental 2D radiography and CBCT imaging [Abstract] [Full Paper]

    Keith Angelino, Edlund D, Bhatia G, Wu S, Shah P*

    (*Senior author supervising research, Selected for oral presentation)

    17th annual IEEE International Conference on BioInformatics and BioEngineering

  5. 2017. Near-infrared imaging for detecting caries and structural deformities in teeth [Abstract] [Full Paper]

    Keith Angelino, Edlund D and Shah P*

    (*Senior author supervising research)

    Journal of Translational Engineering in Health and Medicine, PMID: 28507826

  6. 2016. Design and preliminary evaluation of a wearable device for mass screening of sleep apnea [Abstract] [Full Paper]

    Rohan Puri, Athanasios A, Gill N, Sathya S, Rathod G, Wahi A, Satat G, Majmudar M, Shah P*

    (*Senior author supervising research)

    Conf Proc IEEE Eng Med Biol Soc, PMID: 28268691


  • 2016 - Making healthcare accessible, printable and deployable - INKtalks, Goa, India [YouTube Link]


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